CLIP antibody (full length)

Catalog No. ABIN3026079

The Mouse Monoclonal anti-CLIP antibody is suitable to detect CLIP in samples from Human. It has been validated for WB.

Quick Overview for CLIP antibody (full length) (ABIN3026079)

Target: CLIP (Corticotropin-Like Intermediate Peptide (CLIP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLIP antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Clone: CLIP-1133

Product Details anti-CLIP Antibody

Binding Specificity: full length

Purpose: CLIP Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant full-length human protein was used as the immunogen for the CLIP antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CLIP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the CLIP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CLIP

Target: CLIP (Corticotropin-Like Intermediate Peptide (CLIP))

Alternative Name: CLIP

Background: Recognizes proteins of 33, 35 and 41 kDa, which are identified as various isoforms of CD74/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

UniProt: P04233