Caspase 1 antibody (Large Subunit, N-Term)

Catalog No. ABIN3028535

The Rabbit Polyclonal anti-Caspase 1 antibody has been validated for WB and IHC (p). It is suitable to detect Caspase 1 in samples from Human.

Quick Overview for Caspase 1 antibody (Large Subunit, N-Term) (ABIN3028535)

Target: Caspase 1 (CASP1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Caspase 1 Antibody

Binding Specificity: Large Subunit, N-Term

Purification: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human CASP1 (CSLEEAQRIWKQKSAEIY) was used as the immunogen for this Caspase-1 antibody. The sequence is from the large subunit.

Isotype: IgG

Application Details

Application Notes: Titration of the Caspase-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: The lyophilized Caspase-1 antibody can be stored at 4°C. After reconstitution, aliquot and store at -20°C. Repeated freeze/thaw steps should be avoided.

Target Details for Caspase 1

Target: Caspase 1 (CASP1)

Alternative Name: Caspase-1

Background: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, interleukin 18, and interleukin 33 precursor proteins. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas.

UniProt: P29466

Pathways: Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome