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PIK3R1 antibody (AA 447-461)

PI3K p85a Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3029749
  • Target See all PIK3R1 (PI3K p85a) Antibodies
    PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
    Binding Specificity
    • 18
    • 15
    • 15
    • 15
    • 13
    • 13
    • 8
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 447-461
    Reactivity
    • 139
    • 96
    • 71
    • 18
    • 17
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 123
    • 32
    Rabbit
    Clonality
    • 107
    • 48
    Polyclonal
    Conjugate
    • 79
    • 11
    • 11
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This PIK3R1 antibody is un-conjugated
    Application
    • 121
    • 59
    • 41
    • 28
    • 24
    • 18
    • 17
    • 16
    • 14
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Antigen affinity
    Immunogen
    Amino acids 447-461 (KVYHQQYQDKSREYD-beta specific) was used as the immunogen for this PI3K antibody (100% human, mouse and rat homology).
    Isotype
    IgG
    Top Product
    Discover our top product PI3K p85a Primary Antibody
  • Application Notes
    The stated application concentrations are suggested starting points. Titration of the PI3K antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the PI3K antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
    Alternative Name
    PI3K (PI3K p85a Products)
    Synonyms
    PI3CG antibody, PI3K antibody, PI3Kgamma antibody, PIK3 antibody, AGM7 antibody, GRB1 antibody, p85 antibody, p85-ALPHA antibody, PI3KA antibody, AA414921 antibody, C530050K14 antibody, p50alpha antibody, p55alpha antibody, p85alpha antibody, wu:fb65b05 antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma antibody, phosphoinositide-3-kinase regulatory subunit 1 antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta antibody, phosphoinositide-3-kinase, regulatory subunit 1 (alpha) antibody, PIK3CG antibody, PIK3R1 antibody, Pik3r1 antibody, Pik3cb antibody, pik3r1 antibody
    Background
    Phosphatidylinositol 3-kinase regulatory subunit 2, also called p85-Beta, PIK3R2 and PIK3, is an enzyme that in humans is encoded by the PIK3R2 gene. The NS1 protein from various influenza strains bind p85-beta, but not p85-alpha. Binding of p85-beta and activation of PI3K required tyr89 of NS1, and mutant viruses expressing NS1 with a tyr89-to-phe substitution grew more slowly in cell culture than wildtype viruses. Using mouse embryonic fibroblasts, Park et al. showed that, in addition to regulating PI3K function, p85-alpha/beta regulated the function of Xbp1s, a transcription factor that orchestrates the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress. Overexpression of the protein in livers of ob/ob mice increased glucose tolerance and reduced blood glucose concentrations.
    UniProt
    O00459
    Pathways
    TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effect
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