ANG2 antibody (AA 19-348)

Catalog No. ABIN3029946

This anti-ANG2 antibody is a Rabbit Polyclonal antibody detecting ANG2 in IHC (p). Suitable for Human, Rat and Mouse.

Quick Overview for ANG2 antibody (AA 19-348) (ABIN3029946)

Target: ANG2 (Angiogenin, Ribonuclease A Family, Member 2 (ANG2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANG2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ANG2 Antibody

Binding Specificity: AA 19-348

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 19-348) was used as the immunogen for this ANG2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the ANG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the ANG2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for ANG2

Target: ANG2 (Angiogenin, Ribonuclease A Family, Member 2 (ANG2))

Alternative Name: ANG2

Background: Angiopoietin 2, also known as ANG2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANGPT1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.

Gene ID: 285

Pathways: Carbohydrate Homeostasis