BRSK1 antibody

Catalog No. ABIN303016

This Rabbit Polyclonal antibody specifically detects BRSK1 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.It has been mentioned in 1 publication

Quick Overview for BRSK1 antibody (ABIN303016)

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRSK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BRSK1 Antibody

Specificity: This antibody reacts to a 28 amino acid peptide from near the carboxy terminus of BRSK1.

Purification: Purified

Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Western blot. Immunohistochemistry on paraffin sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline, containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-BRSK1 antibody (ABIN303016)

Zempel, Thies, Mandelkow, Mandelkow: "Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 36, pp. 11938-50, (2010) (PubMed).

Target Details for BRSK1

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Alternative Name: BRSK1

Background: BRSK1 is thought to be involved in the regulation of G2/M arrest and to function as a checkpoint kinase following DNA damage induced by UV or methyl methane sulfonate. BRSK1 phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.Synonyms: BR serine/threonine-protein kinase 1, KIAA1811, SAD-B, SAD1, SAD1 kinase, Serine/threonine kinase SAD-B

Gene ID: 84446

NCBI Accession: NP_115806

UniProt: Q8TDC3