COX1 antibody (AA 318-599)

Catalog No. ABIN3030661

Product Details anti-COX1 Antibody

Target: COX1 (Cytochrome C Oxidase Subunit I (COX1))

Binding Specificity: AA 318-599

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 318-599) was used as the immunogen for this COX1 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the COX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the COX1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for COX1

Target: COX1 (Cytochrome C Oxidase Subunit I (COX1))

Alternative Name: COX1 (COX1 Products)

Synonyms: COX-1 antibody, COI antibody, MTCO1 antibody, COX1 antibody, CoxI antibody, prostaglandin-endoperoxide synthase 1 antibody, cytochrome c oxidase subunit I antibody, cytochrome c oxidase subunit 1 antibody, cytochrome c oxidase 1 antibody, PTGS1 antibody, COX1 antibody, cox1 antibody

Background: Cyclooxygenase 1(COX1), also known as Prostaglandin-endoperoxide synthase (PTGS1) or Mitochondrial cytochrome c oxidase subunit 1, is the key enzyme in prostaglandin biosynthesis. The gene is approximately 40 kb long, with 11 protein-coding exons. It is 599 amino acid residues with a calculated molecular mass of approximately 68 kD. By analysis of a human/hamster somatic hybrid DNA panel, it was demonstrated that the gene maps to chromosome 9. COX1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

UniProt: P23219

Pathways: Proton Transport