COX1 antibody (C-Term)

Catalog No. ABIN6260980

The Rabbit Polyclonal anti-COX1 antibody (ABIN6260980) specifically detects COX1 in WB, IHC, IF and ICC. The antibody is reactive with Human and Rat samples.

Quick Overview for COX1 antibody (C-Term) (ABIN6260980)

Target: COX1 (Cytochrome C Oxidase Subunit I (COX1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-COX1 Antibody

Binding Specificity: C-Term

Purpose: Cox1 Antibody

Specificity: Cox1 Antibody detects endogenous levels of total Cox1.

Predicted Reactivity: Pig,Horse,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Cox1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for COX1

Target: COX1 (Cytochrome C Oxidase Subunit I (COX1))

Alternative Name: Cox1

Background:

Description: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

Gene: PTGS1

Molecular Weight: 70kDa

Gene ID: 5742

UniProt: P23219

Pathways: Proton Transport