Desmoglein 3 antibody (AA 981-999)

Catalog No. ABIN3030722

The Rabbit Polyclonal anti-Desmoglein 3 antibody is suitable to detect Desmoglein 3 in samples from Human. It has been validated for WB.

Quick Overview for Desmoglein 3 antibody (AA 981-999) (ABIN3030722)

Target: Desmoglein 3 (DSG3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoglein 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Desmoglein 3 Antibody

Binding Specificity: AA 981-999

Purpose: Desmoglein 3 Antibody

Purification: Antigen affinity

Immunogen: Amino acids 981-999 (QLRGSHTMLCTEDPCSRLI-human) were used as the immunogen for this Desmoglein 3 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Desmoglein 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Desmoglein 3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Desmoglein 3

Target: Desmoglein 3 (DSG3)

Alternative Name: Desmoglein 3

Background: Desmoglein 3 is also known as PVA (Pemphigus Vulgaris Antigen). Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune diseases of the skin which have as target antigens two different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen (PVA, or Desmoglein 3) in the case of PV and Desmoglein 1 in the case of PF. The DSG3 gene, like the genes for DSG1 and DSG2, is located on chromosome 18. The human DSG3 gene consists of 15 exons and spans more than 23 kb. DSG3 and DSG1 are the autoantigens of pemphigus vulgaris and pemphigus foliaceus, respectively. DSG3 and DSG1 are the target antigens in PNP, and IgG autoantibodies against DSG3 in PNP sera play a pathogenic role in the loss of keratinocyte adhesion and blistering.

UniProt: P32926