MIP antibody (C-Term)

Catalog No. ABIN3031681

This Rabbit Polyclonal antibody specifically detects MIP in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MIP antibody (C-Term) (ABIN3031681)

Target: MIP (Major Intrinsic Protein of Lens Fiber (MIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MIP Antibody

Binding Specificity: C-Term

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of mouse Aquaporin 0 (NGQPEGTGEPVELKTQAL) was used as the immunogen for this Aquaporin 0 antibody (100% rat homology).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Aquaporin 0 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Aquaporin 0 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for MIP

Target: MIP (Major Intrinsic Protein of Lens Fiber (MIP))

Alternative Name: Aquaporin 0

Background: Aquaporin 0, also called Lens fiber major intrinsic protein, MIP26 and MP26, is a protein that in humans is encoded by the MIP gene. It is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. Using 2-color fluorescence in situ hybridization on high-resolution R-banded chromosomes and human genomic DNA clones for MIP as probes, this gene was found that located in close proximity in region 12q13. MIP/Aquaporin 0 plays a crucial role in the development of a transparent eye lens. This gene may be responsible for regulating the osmolarity of the lens and interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

UniProt: P09011