MIP antibody (AA 21-120)

Catalog No. ABIN719576

The Rabbit Polyclonal anti-MIP antibody is suitable to detect MIP in samples from Human. It has been validated for IF (cc), IF (p), IHC (p) and IHC (fro).

Quick Overview for MIP antibody (AA 21-120) (ABIN719576)

Target: MIP (Major Intrinsic Protein of Lens Fiber (MIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIP antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MIP Antibody

Binding Specificity: AA 21-120

Purpose: AQP0 Polyclonal Antibody

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AQP0

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MIP

Target: MIP (Major Intrinsic Protein of Lens Fiber (MIP))

Alternative Name: AQP0

Background:

Synonyms: AQP0, LIM1, MP26, MIP26, CTRCT15, Lens fiber major intrinsic protein, Aquaporin-0, MIP

Background: Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).

Gene ID: 4284

UniProt: P30301