MUC1 antibody (AA 1067-1083)

Catalog No. ABIN3031861

This Rabbit Polyclonal antibody specifically detects MUC1 in WB. It exhibits reactivity toward Human.

Quick Overview for MUC1 antibody (AA 1067-1083) (ABIN3031861)

Target: MUC1 (Mucin 1 (MUC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MUC1 Antibody

Binding Specificity: AA 1067-1083

Purpose: MUC1 Antibody

Purification: Antigen affinity

Immunogen: Amino acids 1067-1083 (QELQRDISEMFLQIYKQ-human) were used as the immunogen for this MUC1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the MUC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MUC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MUC1

Target: MUC1 (Mucin 1 (MUC1))

Alternative Name: MUC1

Background: Mucin 1 protein is encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Family members are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. MUC1 is a transmembrane protein normally expressed on the apical borders of secretory epithelial cells. Overexpression is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. It stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This protein also can suppress pulmonary innate immunity, and its anti-inflammatory activity may play an important modulatory role during microbial infection.

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling