NUMB antibody (AA 194-220)

Catalog No. ABIN3032081

Product Details anti-NUMB Antibody

Target: NUMB (Numb Homolog (NUMB))

Binding Specificity: AA 194-220

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMB antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids 194-220 (SFRVTTATEQAEREEIMKQMQDAKKAE-human) were used as the immunogen for this Numb antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Numb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Numb antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for NUMB

Target: NUMB (Numb Homolog (NUMB))

Alternative Name: Numb (NUMB Products)

Background: Numb is a protein that in humans is encoded by the gene of the same name. The encoded protein, whose degradation is induced in a proteasome-dependent manner by < a href=../search_result.php?search_txt=mdm>MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of < a href=../search_result.php?search_txt=notch>Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. Additionally, the protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

Gene ID: 8650

Pathways: Cell-Cell Junction Organization