Peroxiredoxin 3 antibody (AA 239-256)

Catalog No. ABIN3032188

Product Details anti-Peroxiredoxin 3 Antibody

Target: Peroxiredoxin 3 (PRDX3)

Binding Specificity: AA 239-256

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Peroxiredoxin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Amino acids 239-256 (TIKPSPAASKEYFQKVNQ-human) were used as the immunogen for this Peroxiredoxin 3 antibody.

Isotype: IgG

Application Details

Application Notes: Titration of the Peroxiredoxin 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: The lyophilized Peroxiredoxin 3 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Peroxiredoxin 3

Target: Peroxiredoxin 3 (PRDX3)

Abstract: PRDX3 Products

Synonyms: cb718 antibody, wu:fk49e09 antibody, zgc:110282 antibody, zgc:112512 antibody, MGC83969 antibody, PRDX3 antibody, AOP-1 antibody, AOP1 antibody, HBC189 antibody, MER5 antibody, PRO1748 antibody, SP-22 antibody, prx-III antibody, AW822249 antibody, Aop1 antibody, D0Tohi1 antibody, Ef2l antibody, Mer5 antibody, Prx3 antibody, SP22 antibody, TDXM antibody, MTAP antibody, peroxiredoxin 3 antibody, peroxiredoxin 3 S homeolog antibody, peroxiredoxin PRX3 antibody, prdx3 antibody, PRDX3 antibody, prdx3.S antibody, PRX3 antibody, Prdx3 antibody

Background: Peroxiredoxin 3 is a mitochondrial protein belonging to the AhpC/TSA family. Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that Peroxiredoxin 3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells.

UniProt: P30048

Pathways: Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process