Plakophilin 2 antibody (C-Term)

Catalog No. ABIN3032241

This anti-Plakophilin 2 antibody is a Rabbit Polyclonal antibody detecting Plakophilin 2 in WB. Suitable for Human, Rat and Mouse.

Quick Overview for Plakophilin 2 antibody (C-Term) (ABIN3032241)

Target: Plakophilin 2 (PKP2)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Plakophilin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Plakophilin 2 Antibody

Binding Specificity: C-Term

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human PKP2 (KKTDFVNSRTAKAYHSLKD) was used as the immunogen for this Plakophilin 2 antibody (100% mouse homology).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Plakophilin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Plakophilin 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Plakophilin 2

Target: Plakophilin 2 (PKP2)

Alternative Name: Plakophilin 2

Background: Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. PKP2 is a constituent of the desmosomal plaque in simple epithelia, some stratified epithelia, and some nonepithelial cells. It is also enriched in the karyoplasm of cells of various types, including those lacking desmosomes. PKP proteins participate in linking cadherins to intermediate filaments in the cytoskeleton and this gene product may regulate the signaling activity of beta-catenin. Plakophilin-2 has been shown to interact with Desmoplakin, Plakoglobin and Desmoglein 1.

UniProt: Q99959

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection