PLAT antibody (AA 366-562)

Catalog No. ABIN3032242

Product Details anti-PLAT Antibody

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Binding Specificity: AA 366-562

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAT antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 366-562) was used as the immunogen for this tPA antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the tPA antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the tPA antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: tPA (PLAT Products)

Synonyms: T-PA antibody, TPA antibody, AU020998 antibody, AW212668 antibody, D8Ertd2e antibody, tPA antibody, PATISS antibody, tpa antibody, Plat antibody, plat antibody, t-pa antibody, plasminogen activator, tissue type antibody, plasminogen activator, tissue antibody, chromosome 20 open reading frame 181 antibody, plasminogen activator, tissue L homeolog antibody, PLAT antibody, Plat antibody, plat antibody, C20orf181 antibody, plat.L antibody

Background: Tissue Plasminogen activator (tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. tPA is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Gene ID: 5327

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome