PLAT antibody (AA 366-562)

Catalog No. ABIN3032242

This Rabbit Polyclonal antibody specifically detects PLAT in WB. It exhibits reactivity toward Human.

Quick Overview for PLAT antibody (AA 366-562) (ABIN3032242)

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLAT Antibody

Binding Specificity: AA 366-562

Purpose: tPA Antibody / Tissue Plasminogen Activator

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 366-562) was used as the immunogen for this tPA antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the tPA antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the tPA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: tPA

Background: Tissue Plasminogen activator (tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. tPA is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

UniProt: P00750

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome