Progesterone Receptor antibody (AA 595-933)

Catalog No. ABIN3032309

The Rabbit Polyclonal anti-Progesterone Receptor antibody is suitable to detect Progesterone Receptor in samples from Human and Rat. It has been validated for WB and IHC (p).

Quick Overview for Progesterone Receptor antibody (AA 595-933) (ABIN3032309)

Target: Progesterone Receptor (PGR)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Progesterone Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Progesterone Receptor Antibody

Binding Specificity: AA 595-933

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 595-933) was used as the immunogen for this Progesterone Receptor antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Progesterone Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Progesterone Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Progesterone Receptor

Target: Progesterone Receptor (PGR)

Alternative Name: Progesterone Receptor

Background: The progesterone receptor (PR) is an intracellular steroid receptor that specially binds progesterone in humans. It is encoded by a single PGR gene residing on chromosome 11q22. The PR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. It can be observed in human breast tissues. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner.

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration