SOCS2 antibody (AA 96-198)

Catalog No. ABIN3042487

Product Details anti-SOCS2 Antibody

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Binding Specificity: AA 96-198

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 2(SOCS2) detection. Tested with WB in Human,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 2(SOCS2) detection. Tested with WB in Human,Rat.
Gene Name: suppressor of cytokine signaling 2
Protein Name: Suppressor of cytokine signaling 2

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SOCS2 recombinant protein (Position: R96-V198). Human SOCS2 shares 96.1% and 95.1% amino acid (aa) sequence identity with mouse and rat SOCS2, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat , The detection limit for SOCS2 is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Alternative Name: SOCS2 (SOCS2 Products)

Synonyms: CIS2 antibody, Cish2 antibody, SOCS-2 antibody, SSI-2 antibody, SSI2 antibody, STATI2 antibody, Cish1 antibody, Socs-1 antibody, Socs-2 antibody, si:dkey-202b22.1 antibody, socs2 antibody, cis2 antibody, ssi2 antibody, cish2 antibody, ssi-2 antibody, socs-2 antibody, stati2 antibody, 8030460M17 antibody, AI527257 antibody, AW108012 antibody, D130043N08Rik antibody, JAB antibody, hg antibody, Cradd antibody, Socs2 antibody, suppressor of cytokine signaling 2 antibody, suppressor of cytokine signaling 1 antibody, death domain-containing protein CRADD antibody, suppressor of cytokine signaling 2 S homeolog antibody, SOCS2 antibody, Socs1 antibody, Socs2 antibody, socs2 antibody, LOC100716104 antibody, socs2.S antibody

Background: Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.

Synonyms: CIS 2 antibody|CIS-2 antibody|CIS2 antibody|Cish 2 antibody|Cish2 antibody|Cytokine inducible SH2 protein 2 antibody|Cytokine-inducible SH2 protein 2 antibody|SOCS 2 antibody|SOCS-2 antibody|Socs2 antibody|SOCS2_HUMAN antibody|SSI 2 antibody|SSI-2 antibody|SSI2 antibody|STAT induced STAT inhibitor 2 antibody|STAT-induced STAT inhibitor 2 antibody|STATI 2 antibody|STATI2 antibody|Suppressor of cytokine signaling 2 antibody

Gene ID: 8835

UniProt: O14508

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus