CMA1 antibody (AA 22-247)
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- Target See all CMA1 Antibodies
- CMA1 (Chymase 1, Mast Cell (CMA1))
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Binding Specificity
- AA 22-247
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CMA1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purpose
- Rabbit IgG polyclonal antibody for Chymase(CMA1) detection. Tested with WB, IHC-P in Human.
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for Chymase(CMA1) detection. Tested with WB, IHC-P in Human.
Gene Name: chymase 1, mast cell
Protein Name: Chymase - Purification
- Immunogen affinity purified.
- Immunogen
- E.coli-derived human CMA1 recombinant protein (Position: I22-N247). Human CMA1 shares 75% and 74% amino acid (aa) sequence identity with mouse and rat CMA1, respectively.
- Isotype
- IgG
- Top Product
- Discover our top product CMA1 Primary Antibody
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for CMA1 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- Target
- CMA1 (Chymase 1, Mast Cell (CMA1))
- Alternative Name
- CMA1 (CMA1 Products)
- Synonyms
- CYH antibody, MCT1 antibody, chymase antibody, MMCP-5 antibody, Mcp-5 antibody, Mcp5 antibody, Mcpt5 antibody, MCP3P antibody, CMA1 antibody, Chymase antibody, chymase 1 antibody, chymase 1, mast cell antibody, chymase-like antibody, CMA1 antibody, Cma1 antibody, LOC100008644 antibody
- Background
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Chymase is a major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. Chymase is mapped to 14q12. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II.
Synonyms: Alpha-chymase antibody|Chymase 1 antibody|Chymase 1 mast cell antibody|Chymase antibody|Chymase, heart antibody|Chymase, mast cell antibody|CMA1 antibody|CMA1_HUMAN antibody|CYH antibody|CYM antibody|EC 3.4.21.39 antibody|Mast cell chymase 1 antibody|Mast cell protease 3 antibody|Mast cell protease 5 antibody|Mast cell protease I antibody|Mast cell protease III antibody|Mcp-5 antibody|MCP3P antibody|Mcpt5 antibody|MGC119890 antibody|MGC119891 antibody|MMCP-5 antibody - Gene ID
- 1215
- UniProt
- P23946
- Pathways
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis
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