CYLD antibody (AA 618-956)

Catalog No. ABIN3042782

The Rabbit Polyclonal anti-CYLD antibody is suitable to detect CYLD in samples from Human and Rat. It has been validated for WB.

Quick Overview for CYLD antibody (AA 618-956) (ABIN3042782)

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYLD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CYLD Antibody

Binding Specificity: AA 618-956

Purpose: Anti-CYLD Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human CYLD shares 97.6%,97.9% amino acid (aa) sequence identity with mouse,rat CYLD,respectively.

Characteristics: Anti-CYLD Antibody. Tested in WB applications. This antibody reacts with Human, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CYLD recombinant protein (Position: D618-K956). Human CYLD shares 97.6% and 97.9% amino acid (aa) sequence identity with mouse and rat CYLD, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Rat

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CYLD

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Alternative Name: CYLD

Background:

Background: CYLD is localized on the long arm of chromosome 16. This gene encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Full Name: CYLD lysine 63 deubiquitinase

Sequence Similarities: Belongs to the peptidase C19 family.

Molecular Weight: 107 kDa

Gene ID: 1540

UniProt: Q9NQC7

Pathways: Apoptosis, Activation of Innate immune Response