IL2 Receptor beta antibody (C-Term)

Catalog No. ABIN3043246

This Rabbit Polyclonal antibody specifically detects IL2 Receptor beta in WB. It exhibits reactivity toward Mouse.

Quick Overview for IL2 Receptor beta antibody (C-Term) (ABIN3043246)

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL2 Receptor beta antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL2 Receptor beta Antibody

Binding Specificity: C-Term

Purpose: Anti-IL2 Receptor beta/IL2RB Antibody

Sequence: NLHGQDQDRG QGPILTLNTD AYLSLQELQA QDSVHLI

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related human sequence by sixteen amino acids,and from the related rat sequence by fourteen amino acids.

Characteristics: Anti-IL2 Receptor beta/IL2RB Antibody. Tested in WB applications. This antibody reacts with Mouse.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse IL2RB, different from the related human sequence by sixteen amino acids, and from the related rat sequence by fourteen amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IL2 Receptor beta

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Alternative Name: Il2rb

Background:

Background: IL2RB (INTERLEUKIN 2 RECEPTOR, BETA), also called CD122, is a protein that in humans is encoded by the IL2RB gene. The gene represents the beta subunit and is a type I membrane protein. IL2RB is mapped to 22q12.3. The IL2RB gene contains 10 exons spanning about 24.3 kb and that the gene product is encoded by exons 2-10. The IL2 receptor is present in 3 forms with respect to binding ability to IL2: high, intermediate, and low affinity forms. Analysis of mutants of the beta chain of the IL2 receptor reveals that the granulocyte and monocyte differentiation signals are triggered by different cytoplasmic domains, showing that the signaling pathways responsible for these unique developmental outcomes are separable.

Gene Full Name: interleukin 2 receptor, beta chain

Molecular Weight: 75 kDa

Gene ID: 16185

UniProt: P16297

Pathways: JAK-STAT Signaling, Growth Factor Binding