POT1 antibody (N-Term)

Catalog No. ABIN3043444

Product Details anti-POT1 Antibody

Target: POT1 (Protection of Telomeres 1 (POT1))

Binding Specificity: AA 195-234, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POT1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Protection of telomeres protein 1(POT1) detection. Tested with WB in Human.

Sequence: RVLIQDLVLE GDLSHIHRLQ NLTIDILVYD NHVHVARSLK

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Protection of telomeres protein 1(POT1) detection. Tested with WB in Human.
Gene Name: protection of telomeres 1
Protein Name: Protection of telomeres protein 1

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human POT1 (195-234aa RVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLK), different from the related mouse sequence by eleven amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Alternative Name: POT1 (POT1 Products)

Synonyms: HPOT1 antibody, POT1 antibody, DKFZp469P1825 antibody, pot1 antibody, 1500031H18Rik antibody, AI851169 antibody, Pot1 antibody, Pot1a antibody, protection of telomeres 1 antibody, protection of telomeres 1 L homeolog antibody, protection of telomeres 1A antibody, POT1 antibody, pot1.L antibody, Pot1a antibody, Pot1 antibody

Background: Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene. This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Synonyms: DKFZP586D211 antibody|hPot 1 antibody|hPot1 antibody|POT 1 antibody|POT1 antibody|POT1 like telomere end-binding protein antibody|POT1 protection of telomeres 1 homolog antibody|POT1-like telomere end-binding protein antibody|POTE1_HUMAN antibody|Protection of telomeres 1 antibody|Protection of telomeres 1 homolog (S. pombe) antibody|Protection of telomeres protein 1 antibody

Gene ID: 25913

Pathways: Cell Division Cycle, Telomere Maintenance