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MMP7 antibody (AA 1-267)

MMP7 Reactivity: Human WB, ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3043880
  • Target See all MMP7 Antibodies
    MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))
    Binding Specificity
    • 16
    • 14
    • 11
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-267
    Reactivity
    • 78
    • 37
    • 29
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 80
    • 16
    • 2
    Rabbit
    Clonality
    • 83
    • 14
    Polyclonal
    Conjugate
    • 46
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MMP7 antibody is un-conjugated
    Application
    • 72
    • 43
    • 31
    • 22
    • 13
    • 13
    • 11
    • 10
    • 9
    • 9
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Matrilysin(MMP7) detection. Tested with WB, IHC-P, ELISA in Human.
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Matrilysin(MMP7) detection. Tested with WB, IHC-P, ELISA in Human.
    Gene Name: matrix metallopeptidase 7 (matrilysin, uterine)
    Protein Name: Matrilysin
    Purification
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human MMP7 recombinant protein (Position: M1-K267). Human MMP7 shares 71% amino acid (aa) sequences identity with both mouse and rat MMP7.
    Isotype
    IgG
    Top Product
    Discover our top product MMP7 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MMP7 is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Li, Xiao, Li, Li, Zeng, Liu, Liang, Li, Chu, Yang: "Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1715-1722, (2018) (PubMed).

    Jia, Jiang, Liu, Wang, Zhu, Zhu, Liu, Zhong, Xie, Huang, Jia, Li, Liu, Zuo, Cheng, Dai, Ren: "Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells." in: International journal of oncology, Vol. 52, Issue 6, pp. 1787-1800, (2018) (PubMed).

    Bai, Luo: "5-Hydroxy-4'-Nitro-7-Propionyloxy-Genistein Inhibited Invasion and Metastasis via Inactivating Wnt/b-Catenin Signal Pathway in Human Endometrial Carcinoma Ji Endometrial Cells." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 3230-3243, (2018) (PubMed).

    Xu, Xu, Li, Wang, Fu, Jia, Wang, Zhu, Lu, Yao: "Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3β/β-catenin signaling." in: Oncotarget, Vol. 8, Issue 10, pp. 16972-16987, (2017) (PubMed).

    Gao, Tang, He, Liu, Mao, Ji, Lin, Wu: "Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats." in: Frontiers in pharmacology, Vol. 6, pp. 215, (2015) (PubMed).

    Yang, Gao, Rao, Zhang, Ouyang, Yang: "Antisense oligonucleotide targeting matrix metalloproteinase-7 (MMP-7) changes the ultrastructure of human A549 lung adenocarcinoma cells." in: Ultrastructural pathology, Vol. 35, Issue 6, pp. 256-9, (2011) (PubMed).

    Yang, Shi, Li, Yi: "Effects of shRNA targeting maspin on invasion of gastric carcinoma SGC7901 cell line." in: Oncology reports, Vol. 25, Issue 1, pp. 259-65, (2010) (PubMed).

    Pan, Zhang, Xu, Meng, Zhang, Xue, Han, Li: "Beta-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription." in: Histochemistry and cell biology, Vol. 134, Issue 3, pp. 285-95, (2010) (PubMed).

  • Target
    MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))
    Alternative Name
    MMP7 (MMP7 Products)
    Synonyms
    MAT antibody, MPMM antibody, MMP-7 antibody, MPSL1 antibody, PUMP-1 antibody, matrilysin antibody, LOC727698 antibody, MMP7 antibody, Matrilysin antibody, matrix metallopeptidase 7 antibody, MMP7 antibody, Mmp7 antibody
    Background
    Matrix metalloproteinase-7 (MMP-7) previously called putative metalloproteinase I (PUMP1) or matrilysin. The MMP-7 gene has been identified through studies of collagenase-related connective-tissue-degrading metalloproteinases produced by human tumors. The MMP-7 protein has 267 amino acids and is significantly shorter than stromelysin or collagenase (477 and 469 amino acids, respectively). Matrix metalloproteinases play a crucial role in tumor invasion and metastasis. MMP-7, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain. In addition, MMP-7 mRNA is regulated in a specific and distinct manner in normal and malignant tissues. MMP-7 has been shown to correlate with nodal or distant metastasis in colorectal carcinomas, however, its implication in early invasive colorectal carcinomas has not been determined. MMP-7 is also a mediator of pulmonary fibrosis and a potential therapeutic target. The standard product used in this kit is recombinant human MMP-7, consisting of 250 amino acids with the molecular mass of 28KDa. The detected MMP-7 includes zymogen and active enzyme.

    Synonyms: Matrilysin antibody|Matrilysin uterine antibody|Matrin antibody|Matrix Metalloproteinase 7 antibody|Matrix metalloproteinase-7 antibody|MMP 7 antibody|MMP-7 antibody|MMP7 antibody|MMP7_HUMAN antibody|MPSL1 antibody|PUMP 1 antibody|Pump 1 protease antibody|Pump-1 protease antibody|PUMP1 antibody|Uterine Matrilysin antibody|Uterine metalloproteinase antibody
    Gene ID
    4316
    UniProt
    P09237
    Pathways
    Production of Molecular Mediator of Immune Response
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