PAK3 antibody (N-Term)

Catalog No. ABIN3044532

Product Details anti-PAK3 Antibody

Target: PAK3

Binding Specificity: AA 13-49, N-Term

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK3 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase PAK 3(PAK3) detection. Tested with WB in Human,Mouse,Rat.

Sequence: APPLRMNSNN RDSSALNHSS KPLPMAPEEK NKKARLR

Cross-Reactivity (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase PAK 3(PAK3) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: p21 protein (Cdc42/Rac)-activated kinase 3
Protein Name: Serine/threonine-protein kinase PAK 3

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human PAK3 (13-49aa APPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLR), identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for PAK3

Target: PAK3

Alternative Name: PAK3 (PAK3 Products)

Synonyms: CDKN1A antibody, MRX30 antibody, MRX47 antibody, OPHN3 antibody, PAK3beta antibody, bPAK antibody, hPAK3 antibody, PAK-3 antibody, Pak65alpha antibody, Pak65beta antibody, Stk4 antibody, beta-PAK antibody, XPak3 antibody, bpak antibody, cdkn1a antibody, mrx30 antibody, mrx47 antibody, ophn3 antibody, pak3 antibody, pak3-A antibody, pak3beta antibody, p21 (RAC1) activated kinase 3 antibody, p21 protein (Cdc42/Rac)-activated kinase 3 antibody, p21 protein (Cdc42/Rac)-activated kinase 3 L homeolog antibody, PAK3 antibody, Pak3 antibody, pak3.L antibody

Background: Serine/threonine-protein kinase PAK 3 is an enzyme that in humans is encoded by the PAK3 gene. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.

Synonyms: Beta PAK antibody|bPAK antibody|CDKN1A antibody|hPAK3 antibody|Mental retardation X linked 30 antibody|MRX30 antibody|MRX47 antibody| Oligophrenin 3 antibody|OPHN3 antibody|p21 (CDKN1A) activated kinase 3 antibody|p21 activated kinase 3 antibody|p21 CDKN1A activated kinase 3 antibody|P21 protein (Cdc42/Rac) activated kinase 3 antibody|PAK-3 antibody|PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 antibody|PAK3beta antibody|Pak65alpha antibody|Pak65beta antibody|Serine threonine protein kinase PAK 3 antibody|Stk4 antibody

Gene ID: 5063

UniProt: O75914