SIX Homeobox 1 antibody (C-Term)

Catalog No. ABIN3044544

This anti-SIX Homeobox 1 antibody is a Rabbit Polyclonal antibody detecting SIX Homeobox 1 in WB. Suitable for Human.

Quick Overview for SIX Homeobox 1 antibody (C-Term) (ABIN3044544)

Target: SIX Homeobox 1 (SIX1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIX Homeobox 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIX Homeobox 1 Antibody

Binding Specificity: AA 245-282, C-Term

Purpose: Anti-SIX1 Antibody Picoband®

Sequence: NYSLPGLTAS QPSHGLQTHQ HQLQDSLLGP LTSSLVDL

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-SIX1 Antibody Picoband® (ABIN3044544). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SIX1, different from the related mouse sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. "Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)". 2. Boucher CA, Carey N, Edwards YH, Siciliano MJ, Johnson KJ (Apr 1996). "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics 33 (1): 140-2. 3. Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F (May 2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences of the United States of America 101 (21): 8090-5.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for SIX Homeobox 1

Target: SIX Homeobox 1 (SIX1)

Alternative Name: SIX1

Background:

Synonyms: Homeobox protein SIX1,Sine oculis homeobox homolog 1,SIX1,

Tissue Specificity: Specifically expressed in skeletal muscle.

Background: Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene. It is mapped to 14q23.1. The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).

Molecular Weight: 37 kDa

Gene ID: 6495

UniProt: Q15475

Pathways: Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development