TARDBP antibody (AA 1-260)

Catalog No. ABIN306465

The Mouse Monoclonal anti-TARDBP antibody (Clone k1B8) (ABIN306465) specifically detects TARDBP in WB, IHC, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for TARDBP antibody (AA 1-260) (ABIN306465)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: K1B8

Product Details anti-TARDBP Antibody

Binding Specificity: AA 1-260

Purpose: Human TDP-43/TARDBP antibody

Purification: Purified

Immunogen: Recombinant human TARDBP (1-260aa) purified from E. coli

Isotype: IgG1 kappa

Application Details

Application Notes: Recommended dilution 1:1000(W.B), Recommended dilution 1:100(IHC)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TDP-43/TARDBP

Background: TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.

NCBI Accession: NP_031401

Pathways: Positive Regulation of Peptide Hormone Secretion