TYROBP antibody (Cytoplasmic Domain)

Catalog No. ABIN306916

This Rabbit Polyclonal antibody specifically detects TYROBP in WB and IP. It exhibits reactivity toward Human.

Quick Overview for TYROBP antibody (Cytoplasmic Domain) (ABIN306916)

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYROBP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-TYROBP Antibody

Binding Specificity: Cytoplasmic Domain

Cross-Reactivity: Human, Mouse

Characteristics: TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KARAP, TYROBP,DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).

Purification: Ammonium Sulfate Precipitation

Immunogen: Rabbit immunized with recombinant DAP12 protein (cytoplasmic domain).

Application Details

Application Notes: Antibody can be used for immunoprecipitation (2-4 μg/mg of protein lysate). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for TYROBP

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Alternative Name: DAP12

UniProt: O43914