MMP1 antibody

Catalog No. ABIN307116

The Mouse Monoclonal anti-MMP1 antibody (Clone 3B6) (ABIN307116) specifically detects MMP1 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for MMP1 antibody (ABIN307116)

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 3B6

Product Details anti-MMP1 Antibody

Purpose: Mouse anti Human Matrix Metalloproteinase 1 (MMP1)

Cross-Reactivity: Human

Characteristics: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.

Purification: Protein A/G Chromatography

Isotype: IgG1

Application Details

Application Notes: Antibody can be used for Western blotting (1-2 μg/mL) and immunohistochemistry on formalin-fixed paraffin-embedded tissues (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for MMP1

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Alternative Name: Matrix Metalloproteinase 1 (MMP1)

Background: MMP1, MMP-1, CLG, CLGN, Matrix metallopeptidase 1, Interstitial collagenase

UniProt: P03956