CD4 antibody (Biotin)

Catalog No. ABIN3071826

The Mouse Monoclonal anti-CD4 antibody has been validated for FACS. It is suitable to detect CD4 in samples from Human, Rhesus Monkey and Cynomolgus.

Quick Overview for CD4 antibody (Biotin) (ABIN3071826)

Target: CD4

Reactivity: Human, Rhesus Monkey, Cynomolgus

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD4 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: OKT4

Product Details anti-CD4 Antibody (Biotin)

Purpose: CD4 Biotin Antibody

Characteristics: CD4 is a 55kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is a specific marker for T lymphocytes, monocytes, macrophages, and dendritic cells. Through interaction of MHC-II, CD4 facilitates cell-cell interaction, thymic differentiation, and activation of downstream signaling cascades. HIV infection of T-cells is instigated through binding of HIV to CD4. The OKT4 binds to the D3 domain of CD4 and does not inhibit HIV binding.

Purification: Purified

Purity: >95 %

Immunogen: Human peripheral blood T lymphocytes

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS pH 7.2, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CD4

Target: CD4

Alternative Name: CD4

NCBI Accession: NM_000616

UniProt: P01730

Pathways: TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events