PLVAP antibody (Biotin)

Catalog No. ABIN316983

This anti-PLVAP antibody is a Rat Monoclonal antibody detecting PLVAP in FACS and IHC (fro). Suitable for Mouse.

Quick Overview for PLVAP antibody (Biotin) (ABIN316983)

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This PLVAP antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: MECA-32

Product Details anti-PLVAP Antibody (Biotin)

Characteristics: Synonyms: Plasmalemma vesicle protein 1, PV1, PV-1, MECA-32 antigen, FELS, Endothelial cell marker,Endothelial cell surface marker, Endothelial Cell Antigen, Plasmalemma vesicle-associatedprotein, Fenestrated endothelial-linked structure protein

Purification: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry. Immunohistochemistry on frozen sections: 1/10.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,1 mg/mL

Buffer: Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide (NaN3) and 1 % Bovine Serum Albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PLVAP

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Alternative Name: PLVAP

Background: PLVAP is a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.Synonyms: Endothelial Cell Antigen, Endothelial cell marker, Endothelial cell surface marker, FELS, Fenestrated endothelial-linked structure protein, MECA-32 antigen, PV-1, PV1, Plasmalemma vesicle protein 1, Plasmalemma vesicle-associated protein

UniProt: Q9BX97