Glucagon Receptor antibody

Catalog No. ABIN317704

This Rabbit Polyclonal antibody specifically detects Glucagon Receptor in WB and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Glucagon Receptor antibody (ABIN317704)

Target: Glucagon Receptor (GCGR)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glucagon Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Glucagon Receptor Antibody

Specificity: This antibody detects endogenous levels of Glucagon Receptor protein.(region surrounding Lys136)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/1000-1/10000. Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Glucagon Receptor

Target: Glucagon Receptor (GCGR)

Alternative Name: Glucagon Receptor

Background: Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The 56 GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.Synonyms: GCGR, GL-R

Molecular Weight: approx. 54 kDa

Gene ID: 2642

NCBI Accession: NP_000151

UniProt: P47871

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process