Glucagon Receptor antibody
-
- Target See all Glucagon Receptor (GCGR) Antibodies
- Glucagon Receptor (GCGR)
-
Reactivity
- Human, Rat, Mouse
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This Glucagon Receptor antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificity
- This antibody detects endogenous levels of Glucagon Receptor protein.(region surrounding Lys136)
- Cross-Reactivity (Details)
-
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product GCGR Primary Antibody
-
-
- Application Notes
-
ELISA: 1/1000-1/10000. Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- PBS, pH ~7.2, 15 mM Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Target
- Glucagon Receptor (GCGR)
- Alternative Name
- Glucagon Receptor (GCGR Products)
- Synonyms
- GCGR antibody, GGR antibody, GR antibody, glucagon receptor antibody, GCGR antibody, Gcgr antibody
- Background
- Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The 56 GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.Synonyms: GCGR, GL-R
- Molecular Weight
- approx. 54 kDa
- Gene ID
- 2642
- NCBI Accession
- NP_000151
- UniProt
- P47871
- Pathways
- Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
-