Serotonin Receptor 5A antibody

Catalog No. ABIN317727

The Rabbit Polyclonal anti-Serotonin Receptor 5A antibody (ABIN317727) specifically detects Serotonin Receptor 5A in WB, IF and EIA. The antibody is reactive with Human samples.

Quick Overview for Serotonin Receptor 5A antibody (ABIN317727)

Target: Serotonin Receptor 5A (HTR5A)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 5A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-Serotonin Receptor 5A Antibody

Specificity: This antibody detects endogenous levels of Serotonin receptor-5A / SR-5A(region surrounding Leu35).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity-chromatography

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Serotonin Receptor 5A

Target: Serotonin Receptor 5A (HTR5A)

Background: SR-5B, also designated 5-hydroxytryptamine (serotonin) receptor 5B (5-HT5B) and G protein-coupled receptor 134 (GPR134) is a receptor for the monoamine ligand serotonin (5-hydroxytryptamine, 5-HT). Serotonin is a neurotransmitter derived from serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin actions are mediated by receptors that influence the biochemistry of depression, anxiety, sexuality and appetite. Rat SR-5B is present in serotonergic neurons in dorsal raphe (DR) and central superior nucleus (CS, median raphe nucleus). DR cell bodies showing SR-5B mRNA expression are abundant in the medial portions of the nucleus. CS coexpression of SR-5B receptor mRNA with serotonin transporter mRNA is high in the intermediate portions of the nucleus. Serotonin receptors include SR-1-7 (5HT1-7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F. Subtypes within the SR-2 group include SR-2A, -2B and -2C. Subtypes within the SR-5 group include SR-5A and -5B. SR receptors can couple to G proteins that act on either adenylate cyclase or phospholipase C (PLC). The SR-3 class of receptors are ion channels.Synonyms: 5-HT-5, 5-HT-5A, 5-HT5A, 5-hydroxytryptamine receptor 5A

Molecular Weight: approx. 40 kDa

Gene ID: 3361

NCBI Accession: NP_076917

UniProt: P47898

Pathways: JAK-STAT Signaling