Claudin 6 antibody

Catalog No. ABIN317829

The Rabbit Polyclonal anti-Claudin 6 antibody (ABIN317829) specifically detects Claudin 6 in WB, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Claudin 6 antibody (ABIN317829)

Target: Claudin 6 (CLDN6)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Claudin 6 Antibody

Specificity: This antibody detects endogenous levels of Claudin-6 protein.(region surrounding Val118)

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Claudin 6

Target: Claudin 6 (CLDN6)

Alternative Name: Claudin-6 / CLDN6

Background: The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-6 is expressed in differentiated F9 cells that resemble tight junction-bearing viceral endoderm resulting from stimulation with retinoc acid and mediated by RXRα and RARγ. Claudin-6 is absent in mouse brain and lung. The human claudin-6 gene maps to chromosome 16p13.3.Synonyms: PRO1488, Skullin, Skullin 2, UNQ757

Molecular Weight: approx. 26 kDa

Gene ID: 9074

NCBI Accession: NP_067018

UniProt: P56747

Pathways: Hepatitis C