MUC1 antibody

Catalog No. ABIN3222739

This Mouse Monoclonal antibody specifically detects MUC1 in IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for MUC1 antibody (ABIN3222739)

Target: MUC1 (Mucin 1 (MUC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUC1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MUC1 Antibody

Specificity: Specific for the tandem repeat of the MUC-1 core. Recognizes the hexapeptide (TRPAPG). The MUC-1 mucin (Cancer Antigen CA15-3) is secreted from tumor cells. The apo-protein of the MUC-1 mucin contains a transmembrane domain, a cytoplasmic domain, and an extracellular carbohydrate rich domain. The extracellular domain is characterized by polymorphism with respect to the number of a 20 amino acid tandem repeat (VNTR polymorphism).

Characteristics: Host: Hybridization of P3X63-Ag8.653, myeloma cells with spleen cells from Balb/c mice.

Purification: Purified by Protein A chromatography

Purity: > 98 % pure

Immunogen: Human breast cancer cell line ZR 75-1

Isotype: IgG1

Application Details

Application Notes: Capture or detection antibody in serological assays for the research of antigen MUC-1. Forms a suitable pair withX108 , Catalog # L1C00802. Immunohistochemistry on frozen or paraffin sections for the detection of MUC-1. Immunochemical detection of MUC-1 protein.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1:1000~5000

Buffer: 150mM NaCl 10mM Tris, pH7.4

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for MUC1

Target: MUC1 (Mucin 1 (MUC1))

Alternative Name: CA15-3

Background: Monoclonal Antibody to Carbohydrate Antigen 15-3(CA15-3) (Breast Cancer)

Pathways: Negative Regulation of intrinsic apoptotic Signaling