CD36 antibody (Extracellular Domain)

Catalog No. ABIN350201

The Rabbit Polyclonal anti-CD36 antibody has been validated for WB and IHC. It is suitable to detect CD36 in samples from Human.

Quick Overview for CD36 antibody (Extracellular Domain) (ABIN350201)

Target: CD36

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD36 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CD36 Antibody

Binding Specificity: Extracellular Domain

Purpose: Rabbit antibody to CD36

Specificity: Specific for CD36.

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from extracellular domain of human CD36 (Fatty acid translocase) conjugated to blue carrier protein was used as the antigen.

Application Details

Application Notes: IHC WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for CD36

Target: CD36

Alternative Name: CD36

Background: FUNCTION: Seems to have numerous potential physiological functions. Recent compelling evidence from rodent and human studies raise the possibility for an additional sixth taste modality devoted to the perception of lipids. Recent studies strongly suggest that lingual CD36 being implicated in the perception of dietary fat may act as a gustatory lipid sensor (1). Binds to collagen thrombospondin anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Defects in CD36 are the cause of platelet glycoprotein IV deficiency, also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets but expression in monocytes/macrophages is near normal. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein.

UniProt: P16671

Pathways: TLR Signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteins