PITX2 antibody (C-Term)

Catalog No. ABIN356913

Product Details anti-PITX2 Antibody

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PITX2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects PITX2 at C-term.

Purification: Protein A column, followed by peptide affinity purification

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PILX2.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000. Western blot 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for PITX2

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Alternative Name: PITX2 (PITX2 Products)

Synonyms: ARP1 antibody, Brx1 antibody, IDG2 antibody, IGDS antibody, IGDS2 antibody, IHG2 antibody, IRID2 antibody, Otlx2 antibody, PTX2 antibody, RGS antibody, RIEG antibody, RIEG1 antibody, RS antibody, 9430085M16Rik antibody, Brx1a antibody, Brx1b antibody, Munc30 antibody, Pitx2a antibody, Pitx2b antibody, Pitx2c antibody, Pitx2cbeta antibody, Ptx2 antibody, Rieg antibody, pitx2a antibody, pitx2c antibody, zgc:110508 antibody, XPtx2b antibody, xPtx2 antibody, xpitx2 antibody, arp1 antibody, brx1 antibody, idg2 antibody, igds antibody, igds2 antibody, ihg2 antibody, irid2 antibody, otlx2 antibody, pitx2-A antibody, ptx2 antibody, rgs antibody, rieg antibody, rieg1 antibody, pitx-2 antibody, pitx2 antibody, paired like homeodomain 2 antibody, paired-like homeodomain transcription factor 2 antibody, paired-like homeodomain 2 antibody, paired like homeodomain 2 S homeolog antibody, paired like homeodomain 2 L homeolog antibody, PITX2 antibody, Pitx2 antibody, pitx2 antibody, pitx2.S antibody, pitx2.L antibody

Background: Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.Synonyms: ALL1-responsive protein ARP1, ARP1, Paired-like homeodomain transcription factor 2, Pituitary homeobox 2, RGS, RIEG, RIEG bicoid-related homeobox transcription factor, RIEG1, Solurshin

Gene ID: 5308, 9606

UniProt: Q99697

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development