KREMEN1 antibody (N-Term)

Catalog No. ABIN357077

The Rabbit Polyclonal anti-KREMEN1 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect KREMEN1 in samples from Human.

Quick Overview for KREMEN1 antibody (N-Term) (ABIN357077)

Target: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KREMEN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-KREMEN1 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects Kremen at N-term.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Kremen.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for KREMEN1

Target: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Alternative Name: Kremen Protein 1

Background: Kremen is a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains.Synonyms: Dickkopf receptor, KREMEN, KREMEN1, KRM1, Kringle domain-containing transmembrane protein 1, Kringle-containing protein marking the eye and the nose

Molecular Weight: 63,201 Da

Gene ID: 83999

NCBI Accession: NP_001034659

UniProt: Q96MU8

Pathways: WNT Signaling