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GPLD1 antibody (C-Term)

GPLD1 Reactivity: Human WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN357724
  • Target See all GPLD1 Antibodies
    GPLD1 (Glycosylphosphatidylinositol Specific phospholipase D1 (GPLD1))
    Binding Specificity
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 61
    • 19
    • 18
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 58
    • 3
    Rabbit
    Clonality
    • 60
    • 1
    Polyclonal
    Conjugate
    • 19
    • 7
    • 7
    • 7
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPLD1 antibody is un-conjugated
    Application
    • 56
    • 34
    • 13
    • 13
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects GPLD1 (C-term).
    Purification
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GPLD1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GPLD1 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blot: 1/100-1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    GPLD1 (Glycosylphosphatidylinositol Specific phospholipase D1 (GPLD1))
    Alternative Name
    GPLD1 / GPI-PLD (GPLD1 Products)
    Synonyms
    GPIPLD antibody, GPIPLDM antibody, PIGPLD antibody, PIGPLD1 antibody, 6330541J12Rik antibody, AW546131 antibody, glycosylphosphatidylinositol specific phospholipase D1 antibody, glycosylphosphatidylinositol specific phospholipase d1 antibody, GPLD1 antibody, gpld1 antibody, Micau_0957 antibody, ML5_1205 antibody, VAB18032_09490 antibody, Gpld1 antibody
    Background
    GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.Synonyms: GPI-specific phospholipase D, Glycoprotein phospholipase D, Glycosyl-phosphatidylinositol-specific phospholipase D, PI-G PLD, PIGPLD1, Phosphatidylinositol-glycan-specific phospholipase D
    Molecular Weight
    92666 Da
    Gene ID
    2822, 9606
    UniProt
    P80108
    Pathways
    Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process
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