ERN2 antibody (C-Term)

Catalog No. ABIN359269

This Rabbit Polyclonal antibody specifically detects ERN2 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for ERN2 antibody (C-Term) (ABIN359269)

Target: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERN2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ERN2 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to ERN2.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ERN2.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for ERN2

Target: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Background: ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.Synonyms: Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, Ire1-beta, Serine/threonine-protein kinase/endoribonuclease IRE2

Gene ID: 10595, 9606

UniProt: Q76MJ5