PLK2 antibody (C-Term)

Catalog No. ABIN359469

This anti-PLK2 antibody is a Rabbit Polyclonal antibody detecting PLK2 in WB, IHC (p) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for PLK2 antibody (C-Term) (ABIN359469)

Target: PLK2 (Polo-Like Kinase 2 (PLK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-PLK2 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects PLK2 (SNK) at C-term.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SNK.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000. Western blot 1: 100 - 1-500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for PLK2

Target: PLK2 (Polo-Like Kinase 2 (PLK2))

Alternative Name: PLK2 / SNK

Background: Plks (polo-like kinases) encode serine/threonine kinases that are closelyrelated to polo and CDC5, genes that are required for passage through mitosisin Drosophila and Saccharomyces, respectively. Polo-like kinases, whichinclude Plk, Snk (for serum-inducible kinase, also designated Plk2) and Fnk(for FGF-inducible kinase, also designated Plk3 or PRK), play a role in cellproliferation. Plk protein accumulates in the cell during S and G2 phases ofthe cell cycle, and both protein content and catalytic activity peak at theonset of mitosis, followed by a rapid reduction after mitosis. Snk and Fnk areimmediate-early response genes that are first expressed during G1 phase. SNK may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia SNK mRNA is rapidly induced in human lung fibroblasts upon reintroduction of serum following 36 hours of serum deprivation.Synonyms: PLK-2, Polo-like kinase 2, Serine/threonine-protein kinase PLK2, Serine/threonine-protein kinase SNK, Serum-inducible kinase

Molecular Weight: 78236 Da

Gene ID: 10769, 9606

UniProt: Q9NYY3