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PLK2 antibody (Internal Region)

PLK2 Reactivity: Human, Mouse, Rat WB, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259281
  • Target See all PLK2 Antibodies
    PLK2 (Polo-Like Kinase 2 (PLK2))
    Binding Specificity
    • 11
    • 8
    • 8
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 56
    • 26
    • 23
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 55
    • 1
    Rabbit
    Clonality
    • 56
    Polyclonal
    Conjugate
    • 29
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PLK2 antibody is un-conjugated
    Application
    • 46
    • 36
    • 21
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    PLK2 Antibody detects endogenous levels of total PLK2.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PLK2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PLK2 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    PLK2 (Polo-Like Kinase 2 (PLK2))
    Alternative Name
    PLK2 (PLK2 Products)
    Synonyms
    SNK antibody, hPlk2 antibody, hSNK antibody, Snk antibody, PLK2 antibody, Plx2 antibody, MGC53990 antibody, plk2 antibody, zgc:165644 antibody, polo like kinase 2 antibody, polo-like kinase 2 antibody, polo-like kinase 2 L homeolog antibody, polo-like kinase 2b (Drosophila) antibody, Serine/threonine-protein kinase plk-2 antibody, PLK2 antibody, Plk2 antibody, plk2.L antibody, plk2b antibody, plk2 antibody, plk-2 antibody
    Background

    Description: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

    Gene: PLK2

    Molecular Weight
    78 kDa
    Gene ID
    10769
    UniProt
    Q9NYY3
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