ROS1 antibody (N-Term)

Catalog No. ABIN359936

The Rabbit Polyclonal anti-ROS1 antibody has been validated for WB, IHC (p), IF and EIA. It is suitable to detect ROS1 in samples from Human.

Quick Overview for ROS1 antibody (N-Term) (ABIN359936)

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ROS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-ROS1 Antibody

Binding Specificity: AA 33-63, N-Term

Specificity: This antibody reacts to ROS.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide between 33~63 amino acids from the N-terminal region of Human ROS.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for ROS1

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Alternative Name: ROS1

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).Synonyms: Proto-oncogene tyrosine-protein kinase ROS, ROS, Tyrosine-protein kinase ROS, c-Ros-1

Gene ID: 6098, 9606

UniProt: P08922

Pathways: RTK Signaling