ROS1 antibody (AA 79-248)

Catalog No. ABIN7166495

Product Details anti-ROS1 Antibody

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Binding Specificity: AA 79-248

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ROS1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Proto-oncogene tyrosine-protein kinase ROS protein (79-248AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ROS1

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Alternative Name: ROS1 (ROS1 Products)

Synonyms: MCF3 antibody, ROS antibody, c-ros-1 antibody, ROS1C antibody, Ros-1 antibody, c-ros antibody, ROS proto-oncogene 1, receptor tyrosine kinase antibody, ROS proto-oncogene 1 , receptor tyrosine kinase antibody, Ros1 proto-oncogene antibody, ROS1 antibody, Ros1 antibody

Background:

Background: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Aliases: c ros 1 antibody, c ros antibody, c ros oncogene 1 receptor tyrosine kinase antibody, c Ros receptor tyrosine kinase antibody, c ros1 antibody, MCF 3 antibody, MCF3 antibody, Oncogene ROS antibody, OTTHUMP00000017814 antibody, OTTHUMP00000017815 antibody, OTTHUMP00000040389 antibody, Proto oncogene c ros 1 protein antibody, Proto oncogene c Ros antibody, Proto oncogene tyrosine protein kinase ROS antibody, Proto oncogene tyrosine protein kinase ROS precursor antibody, Proto-oncogene c-Ros-1 antibody, Proto-oncogene tyrosine-protein kinase ROS antibody, Receptor tyrosine kinase c ros oncogene 1 antibody, Ros 1 antibody, ROS 1C antibody, ROS antibody, ROS proto oncogene 1 , receptor tyrosine kinase antibody, ROS_HUMAN antibody, ROS1 antibody, ROS1C antibody, Transmembrane tyrosine specific protein kinase antibody, v ros avian UR2 sarcoma virus oncogene homolog 1 antibody, v ros UR2 sarcoma virus oncogene homolog 1 antibody

UniProt: P08922

Pathways: RTK Signaling