ROS1 antibody (C-Term)

Catalog No. ABIN6243981

Product Details anti-ROS1 Antibody

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Binding Specificity: AA 1744-1777, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ROS1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ROS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1744-1777 amino acids from the C-terminal region of human ROS1.

Clone: RB50575

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for ROS1

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Alternative Name: ROS1 (ROS1 Products)

Synonyms: MCF3 antibody, ROS antibody, c-ros-1 antibody, ROS1C antibody, Ros-1 antibody, c-ros antibody, ROS proto-oncogene 1, receptor tyrosine kinase antibody, ROS proto-oncogene 1 , receptor tyrosine kinase antibody, Ros1 proto-oncogene antibody, ROS1 antibody, Ros1 antibody

Background: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Molecular Weight: 263915

UniProt: P08922

Pathways: RTK Signaling