IL4 Receptor antibody (Extracellular Domain)

Catalog No. ABIN360908

The Rat Monoclonal anti-IL4 Receptor antibody is suitable to detect IL4 Receptor in samples from Mouse. It has been validated for WB.

Quick Overview for IL4 Receptor antibody (Extracellular Domain) (ABIN360908)

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL4 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 16F23

Product Details anti-IL4 Receptor Antibody

Binding Specificity: Extracellular Domain

Specificity: This antibody detects IL-4R.

Purification: Protein A/G affinity chromatography

Immunogen: Recombinant protein of IL-4R extracellular domain.

Isotype: IgG2

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Alternative Name: CD124 / IL4R

Background: The Interleukin-4 receptor is a complex consisting of two chains. One chain is the high affinity IL-4 binding (p140, a chain, CD 124) chain and the other chain is the gamma chain. The high affinity IL-4 binding chain belongs to the cytokine receptor superfamily. The cytoplasmic domain contains Ser/Pro-rich regions similar to those present in the IL-2 receptor and GM-CSF receptor ß-chains. The recombinant human IL-4 soluble receptor corresponds to the human IL-4 receptor extracellular domain. The recombinant, human IL-4 sR is a potent IL-4 antagonist. This antibody will block IL-4 binding to its receptor.Synonyms: 582J2.1, IL-4R-alpha, IL4 Receptor alpha, IL4RA, Interleukin-4 receptor alpha chain

Gene ID: 16190

NCBI Accession: NP_001008700

UniProt: P16382

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process