Leptin Receptor antibody (Extracellular Domain)

Catalog No. ABIN360927

This anti-Leptin Receptor antibody is a Rat Monoclonal antibody detecting Leptin Receptor in WB. Suitable for Mouse.

Quick Overview for Leptin Receptor antibody (Extracellular Domain) (ABIN360927)

Target: Leptin Receptor (LEPR)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Leptin Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 9C29

Product Details anti-Leptin Receptor Antibody

Binding Specificity: Extracellular Domain

Specificity: This antibody detects Leptin receptor.

Purification: Protein A/G affinity chromatography

Immunogen: Recombinant Leptin R extracellular domain.

Isotype: IgG2

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Leptin Receptor

Target: Leptin Receptor (LEPR)

Alternative Name: CD295 / Leptin Receptor

Background: Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.Synonyms: DB, HuB219, LEP-R, LEPR, OB receptor, OB-R, OBR

Gene ID: 16847

NCBI Accession: NP_001116371

UniProt: P48356

Pathways: JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour