TREM1 antibody (Extracellular Domain)

Catalog No. ABIN360943

This Rat Monoclonal antibody specifically detects TREM1 in WB and IHC (fro). It exhibits reactivity toward Mouse.

Quick Overview for TREM1 antibody (Extracellular Domain) (ABIN360943)

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This TREM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 3C66

Product Details anti-TREM1 Antibody

Binding Specificity: Extracellular Domain

Purification: Affinity Chromatography on Protein A/G.

Immunogen: Purified Mouse Recombinant TREM-1 extracellular domain.

Isotype: IgG2

Application Details

Application Notes: Western blotting: 1/500-1000. Immunohistochemistry on Frozen Sections: 1/50-100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 0.5 mg/mL.

Buffer: PBS without preservatives or stabilizers

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: The lyophilized IgG is stable at 2-8 °C for one month and for one year when kept at -20 °C. Reconstituted antibody can also be aliquotted and stored at -20 °C to -70 °C for 6 months without detectable loss of activity.

Expiry Date: 12 months

Target Details for TREM1

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Alternative Name: TREM1

Background: TREM1 is also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. TREM1 is a Type I membrane protein that contains an immunoglobulin-like V-type domain. An alternatively spliced protein variant may be secreted. TREM1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes), TREM1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock.Synonyms: Triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells 1

Molecular Weight: 26 kDa

NCBI Accession: NM_021406

UniProt: Q9JKE2