SLC6A3 antibody (C-Term)

Catalog No. ABIN361429

This Rabbit Polyclonal antibody specifically detects SLC6A3 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for SLC6A3 antibody (C-Term) (ABIN361429)

Target: SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SLC6A3 Antibody

Binding Specificity: C-Term

Specificity: Specific for the ~88k DAT protein in Western blots. Cross-reaction with rat observed.

Cross-Reactivity: Human, Mouse (Murine), Non-Human Primate

Purification: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic peptide corresponding to amino acid residues from the intracellular C-terminal region conjugated to KLH

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 IHC: (frozen sections, formaldehyde fixed tissue, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Target Details for SLC6A3

Target: SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3))

Alternative Name: SLC6A3

Background: The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson?s disease and drug abuse (Kish et al., 2001, Zhu et al., 2000, Zhu et al., 1999). Levels of DAT protein expression are altered by chronic drug administration (Wilson et al., 1996). Anti-Dopamine Transporter Western blot of human caudate lysate showing specific immunolabeling of the ~88k DAT protein.

Molecular Weight: '88 kDa

Gene ID: 6531

UniProt: Q01959

Pathways: Dopaminergic Neurogenesis