MSH6 antibody (MutS Homolog 6 (E. Coli))

Details for Product anti-MSH6 Antibody No. ABIN379235
Antigen
  • GTBP
  • GTMBP
  • HNPCC5
  • HSAP
  • p160
  • cb326
  • wu:fb36c12
  • LOC100227810
  • AU044881
  • AW550279
  • Gtmbp
  • mutS homolog 6
  • mutS homolog 6 (E. coli)
  • DNA mismatch repair protein
  • MSH6
  • msh6
  • Msh6
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
151
65
44
12
3
2
1
1
1
Host
Mouse
91
57
3
Clonality (Clone)
Monoclonal ()
Conjugate
This MSH6 antibody is un-conjugated
4
3
3
3
3
3
3
2
2
1
1
1
1
1
Application
Immunoprecipitation (IP), Western Blotting (WB)
109
63
54
42
34
13
12
11
10
9
7
6
3
3
3
2
1
Options
Immunogen Synthetic human MSH6 peptide.

Type of Immunogen: Synthetic peptide
Clone 44
Isotype IgG1
Specificity MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. cross reacts with mouse, rat and dog.
Purification Purified
Plasmids, Primers & others Plasmids, Primers & others MSH6 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name MSH6 (MSH6 Antibody Abstract)
Background Name/Gene ID: MSH6

Synonyms: MSH6, GTBP, HSAP, GTMBP, MutS (E. coli) homolog 6, HMSH6, Sperm-associated protein, p160, G/T mismatch-binding protein, HNPCC5, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit
Gene ID 2956
Pathways DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
Application Notes Approved: IP, WB (1:100 - 1:500)
Comment

Target Species of Antibody: Human

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Buffer contains: 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze.
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