MLH1 antibody

Catalog No. ABIN2742949

The Mouse Monoclonal anti-MLH1 antibody (Clone G168-15) (ABIN2742949) specifically detects MLH1 in IHC and IHC (p). The antibody is reactive with Human, Rat and Hamster samples.

Quick Overview for MLH1 antibody (ABIN2742949)

Target: MLH1 (MutL Homolog 1 (MLH1))

Reactivity: Human, Rat, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This MLH1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: G168-15

Product Details anti-MLH1 Antibody

Specificity: The G168-15 antibody recognizes the human and mouse MLH1 (80-85  kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. cross reacts with human, hamster and rat

Immunogen: Full length recombinant MLH.

Type of Immunogen: Recombinant protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid containing sodium azide as a preservative

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for MLH1

Target: MLH1 (MutL Homolog 1 (MLH1))

Alternative Name: MLH1

Background: Name/Gene ID: MLH1

Synonyms: MLH1, COCA2, FCC2, HMLH1, HNPCC, HNPCC2, MutL protein homolog 1

Gene ID: 4292

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response