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JMJD4 antibody (N-Term)

JMJD4 Reactivity: Human WB Host: Rabbit Polyclonal RB10799 unconjugated
Catalog No. ABIN387874
  • Target See all JMJD4 products
    JMJD4 (Jumonji Domain Containing 4 (JMJD4))
    Binding Specificity
    • 8
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivity
    • 26
    • 12
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 26
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    This JMJD4 antibody is un-conjugated
    Application
    • 26
    • 15
    • 8
    • 4
    • 3
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human JMJD4.
    Clone
    RB10799
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    JMJD4 (Jumonji Domain Containing 4 (JMJD4))
    Alternative Name
    JMJD4 (JMJD4 Products)
    Synonyms
    JMJD4 antibody, 6430559I23 antibody, RGD1307186 antibody, jumonji domain containing 4 antibody, jumonji domain containing 4 L homeolog antibody, JMJD4 antibody, jmjd4.L antibody, Jmjd4 antibody
    Background
    Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
    Molecular Weight
    52493
    Gene ID
    65094
    NCBI Accession
    NP_001154937, NP_075383
    UniProt
    Q9H9V9
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